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	<title>Edward Willett &#187; biotechnology</title>
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	<link>http://edwardwillett.com</link>
	<description>Canadian author of science fiction, fantasy and non-fiction for both adults and children.</description>
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		<title>Fuel from germs</title>
		<link>http://edwardwillett.com/2010/01/fuel-from-germs/</link>
		<comments>http://edwardwillett.com/2010/01/fuel-from-germs/#comments</comments>
		<pubDate>Fri, 29 Jan 2010 18:36:44 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
				<category><![CDATA[Blog]]></category>
		<category><![CDATA[Columns]]></category>
		<category><![CDATA[Science Columns]]></category>
		<category><![CDATA[biofuels]]></category>
		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[energy]]></category>
		<category><![CDATA[environment]]></category>
		<category><![CDATA[fuels]]></category>
		<category><![CDATA[genetic engineering]]></category>
		<category><![CDATA[oil]]></category>
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		<guid isPermaLink="false">http://edwardwillett.com/?p=9710</guid>
		<description><![CDATA[For years, we’ve been turning crops such as corn, wheat and sugar beets into fuel, using yeast to convert sugar into alcohol. But there’s an obvious problem with this. That stuff we’re turning into fuel is also food for humans and feed for animals. (And as an aside, how come we always call it “animal [...]]]></description>
			<content:encoded><![CDATA[
<p>For years, we’ve been turning crops such as corn, wheat and sugar beets into fuel, using yeast to convert sugar into alcohol.</p>
<p>But there’s an obvious problem with this. That stuff we’re turning into fuel is also food for humans and feed for animals.</p>
<p>(And as an aside, how come we always call it “animal feed” as opposed to “animal food”? And why don’t we ever refer to “human feed”? Hmm?)</p>
<p>A lot of the plant is wasted when you grow crops for fuel <em>or</em> food. The leaves and stems, with their tough cell walls made of cellulose, hemicellulose and lignin, are more of a nuisance than anything else. Wouldn’t it be great if there were a use for what is now plowed under or burned?</p>
<p>There is, or there soon will be, thanks to research aimed at using bacteria to convert this “lignocellulosic biomass” into fuel in its own right.</p>
<p>A just-published article in <em>Nature</em> reveals the state of the art. Titled “Microbial production of fatty-acid-derived fuels and chemicals from plant biomass,” it describes the successful engineering of the common bacterium <em>Excherichia coli</em>&#8211;better known as <em>E. coli</em> and generally in the news when it contaminates water or meat and makes people sick&#8211;into a producer of biodiesel.</p>
<p>One of the co-authors of the research study is Jay Keasling, chief executive officer for the U.S. Department of Energy’s Joint BioEnergy Institute (JBEI). “We’ve got a billion tons of biomass every year that goes unused,” he says, adding that fuel produced from that biomass could make up for as much as half of U.S. oil imports, turning “the U.S. Midwest into the new ‘Mideast’.”</p>
<p>That’s not hyperbole: by one estimate, lignicellulosic biomass could produce more than 7,500 litres of renewable petroleum per acre.</p>
<p>The researchers modified the <em>E. coli</em> genome, inserting genetic code for the production of an enzyme called hemicellulase, which can break down hemicellulose into smaller sugar molecules which <em>E. coli</em> can then turn into fatty acids.</p>
<p><em>E. coli</em> normally produces only as much of the fatty acids as it needs for its own cell membranes. But the researchers’ <em>E. coli</em> were further modified so that the fatty acids just kept coming, turning each bacterium into a microscopic biodiesel factory.</p>
<p>The process takes place in fermentation vats, into which the bacteria expel little drops of oil. Turn off the impellers, and the oil floats to the top, where it can be skimmed off.</p>
<p>Even better, by tweaking the process, chemical products ranging from solvents to lubricants to jet fuel could conceivably be produced.</p>
<p>Of course, it’s important to note that the research reported in <em>Nature</em> is just a proof of concept. There’s no commercially viable process for doing any of this yet&#8211;but Keasling hopes there will be within a very few years. Work will continue as the researchers search for ways to make use of even more of what’s in the feedstock&#8211;not just the hemicellulose.</p>
<p>There’s already a company standing ready to market fuels and other microbe-produced chemicals. Based in California, LS9, founded by a geneticist and a plant biologist, helped fund the research reported in <em>Nature</em>. LS9 points out that the crude oil produced by bioengineered bacteria has none of the contaminating sulfur of regular crude oil, so it’s cleaner. And despite its unorthodox origins, it can be refined like any other crude oil in a standard refinery.</p>
<p>There are other companies pursuing their own paths. Amyris Biotechnologies, for example, says it has also created bacteria capable of providing renewable hydrocarbon-based fuels. There are many more.</p>
<p>Why would this be preferable to ethanol production as it is currently carried out? Aside from the aforementioned fact that we’re presently turning food into fuel, hydrocarbon fuels are more efficient than ethanol, packing about 30 percent more energy into any given quantity. And even better, they take less energy to produce: ethanol production, which involves distilling, requires 65 percent more energy than hydrocarbon production does.</p>
<p>Perhaps the oil industry will slowly evolve away from the purview of drilling companies and into the realm of agriculture.</p>
<p>As for the marketing slogan for this new germ-produced form of fuel, I think I’ve come up with a winner: “E. coli. It’s not just for food poisoning anymore.”</p>
<p>What do you think?</p>
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		<title>Liquid fuel from solar power</title>
		<link>http://edwardwillett.com/2009/07/liquid-fuel-from-solar-power/</link>
		<comments>http://edwardwillett.com/2009/07/liquid-fuel-from-solar-power/#comments</comments>
		<pubDate>Tue, 28 Jul 2009 20:42:05 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
				<category><![CDATA[Blog]]></category>
		<category><![CDATA[Columns]]></category>
		<category><![CDATA[Science Columns]]></category>
		<category><![CDATA[biofuels]]></category>
		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[energy]]></category>
		<category><![CDATA[environment]]></category>
		<category><![CDATA[fuels]]></category>
		<category><![CDATA[genetic engineering]]></category>
		<category><![CDATA[oil]]></category>
		<category><![CDATA[science]]></category>
		<category><![CDATA[transportation]]></category>

		<guid isPermaLink="false">http://edwardwillett.com/?p=9464</guid>
		<description><![CDATA[In recent years, scientists and engineers have turned to biofuels—fuels generated from living things, and hence renewable—as a means of weaning us off of fossil fuels in favor of something cleaner, less likely to run out, and less wrapped up in international geopolitics. Fermenting the sugars found in corn or other grains into ethanol has [...]]]></description>
			<content:encoded><![CDATA[
<p>In recent years, scientists and engineers have turned to biofuels—fuels generated from living things, and hence renewable—as a means of weaning us off of fossil fuels in favor of something cleaner, less likely to run out, and less wrapped up in international geopolitics.</p>
<p>Fermenting the sugars found in corn or other grains into ethanol has been around for a long time, of course, and it’s pretty much a proven technology. On the other hand, do we really want to be turning food into fuel?</p>
<p>More promising have been recent advances in turning lignocellulose, the stuff that makes up the cell walls in plants, into ethanol and other fuels: that would allow us to use grasses, wood chips, straw and other non-food as biomass.</p>
<p>Now comes word of a fuel-producing technology that doesn’t require biomass of any sort: just carbon dioxide and sunlight. And no, I’m not talking about trees.</p>
<p>On Monday, a Massachussetts company called <a href="http://joulebio.com/">Joule Biotechnologies</a> announced that it has the technology to convert carbon dioxide directly into transportation fuels and chemicals. Not only that, they say, “this eco-friendly, direct-to-fuel conversion requires no agricultural land or fresh water.”</p>
<p>The company was founded in 2007, and relies on something it calls “Helioculture” technology, mixing, as the <em><a href="http://www.nytimes.com/gwire/2009/07/27/27greenwire-start-ups-biofuel-recipe-mixes-co2-slime-and-su-7562.html">New York Times</a></em>’s article on the announcement puts it, “CO2, Slime and Sunshine.”</p>
<p>More specifically, the company grows genetically engineered microorganisms in specially designed bioreactors. The microorganisms are photosynthetic, able to use energy from the sun to convert carbon dioxide and water into ethanol or hydrocarbon fuels.</p>
<p>The process works well in the laboratory, so the real question is if it can be scaled up to an industrial-sized plant. To find out, Joule plans to break ground on a modular pilot plant early in 2010 that will produce ethanol (trademarked as SolarEthanol), and the following year hopes to begin construction on a commercial-scale operation that can also produce hydrocarbons and associated chemicals, “several of which have already been demonstrated at laboratory scale.</p>
<p>It’s looking for sites near CO2 producers such as coal-fired power plants and cement kilns, with locations in Texas, Arizona, Nevada and New Mexico, places with lots of sun and lots of space, under consideration</p>
<p>Open spaces are needed because a large plant would look a lot like a solar array: a huge field covered with panels, except these panels, rather than producing electricity, would produce liquid fuels</p>
<p>The company estimates that a single acre covered with its “SolarConverter” panels (flat, transparent, and about the size of a sheet of plywood) could produce 20,000 gallons of ethanol at a cost of $50 a barrel. (That makes it competitive with oil, although it’s worth noting that that price includes existing subsidies: what the unsubsidized cost would be, I don’t know.)</p>
<p>At that level of production, if you built enough plants to cover, in total, an area the size of the Texas panhandle, you could meet all of the United States’ transportation fuel needs.</p>
<p>In <em><a href="http://www.technologyreview.com/business/23073/">Technology Review</a></em>, writer Kevin Bullis notes that the company’s technology sounds similar to that of biofuels produced by algae—but the company says it is not using algae, and its stated production estimates are an order of magnitude greater than algae-based biofuels, which are estimated to have potential yields of only 2,000 to 6,000 gallons per acre.</p>
<p>Its estimated cost of production is also only a fraction of that of algae-based biofuels, which currently would require crude oil to rise to $800 a barrel in order to be competitive.</p>
<p>Besides, algae produces oils that have to be refined, whereas Joule says its microorganisms will produce ethanol or hydrocarbons directly. The Joule microorganisms also excrete the fuels, whereas algae has to be harvested and processed to extract oil.</p>
<p>Too good to be true? Maybe. But there are other companies in the race to develop the same kinds of technology. And with the push to reduce carbon dioxide emissions and move away from fossil fuels, that race is only going to get hotter.</p>
<p>So remember the name: Joule Biotechnologies.</p>
<p>Someday, its genetically modified critters could be cheerfully churning out the fuel that powers your car.</p>
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		<title>A bunch of stuff I wrote about biomass hits the Web</title>
		<link>http://edwardwillett.com/2008/12/a-bunch-of-stuff-i-wrote-about-biomass-hits-the-web/</link>
		<comments>http://edwardwillett.com/2008/12/a-bunch-of-stuff-i-wrote-about-biomass-hits-the-web/#comments</comments>
		<pubDate>Thu, 11 Dec 2008 04:38:00 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
				<category><![CDATA[Blog]]></category>
		<category><![CDATA[agriculture]]></category>
		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[science]]></category>
		<category><![CDATA[writing]]></category>

		<guid isPermaLink="false">http://sillybean.wordpress.com/2008/12/11/a-bunch-of-stuff-i-wrote-about-biomass-hits-the-web/</guid>
		<description><![CDATA[Earlier this year I wrote a lot of fact sheets about various aspects of biomass for Agriculture and Agri-Food Canada. Those fact sheets are now online: you can drill down from the main page. The largest section of what I wrote dealt with agricultural residue. Here&#8217;s what&#8217;s on that page, with links leading to more [...]]]></description>
			<content:encoded><![CDATA[<p>Earlier this year I wrote a lot of fact sheets about various aspects of biomass for <a href="http://www.agr.gc.ca/index_e.php">Agriculture and Agri-Food Canada</a>. Those fact sheets are now online: you can drill down from <a href="http://www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1226356636533&amp;lang=e">the main page</a>.</p>
<p>The largest section of what I wrote dealt with <a href="http://www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1226510406028&amp;lang=e">agricultural residue</a>. Here&#8217;s what&#8217;s on that page, with links leading to more detailed information:<br />
<blockquote><span style="font-style:italic;">
<div class="center">    <span style="font-weight:bold;">Agriculture Residue</span>
<p><strong><a title="Cereal Straw" href="http://www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1226510850966&amp;lang=e">Cereal Straw</a></strong><br />Cereal straw is the dry stalk of a cereal plant, left behind in the field after the grain or seed has been removed during combining. It is the most abundant of all agricultural residues in Canada for one simple reason: of the approximately 36.4 million hectares of available cropland, more than 85 percent, or about 32 million hectares, are found in the three prairie provinces of Alberta, Saskatchewan and Manitoba, and in those provinces, cereal crops predominate.</p>
<p><strong><a title="Corn Stover" href="http://www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1226595533096&amp;lang=e">Corn Stover</a></strong><br />Corn stover is what remains on the field after corn has been harvested. It consists of approximately 50 percent stalks, 22 percent leaves, 15 percent cob, and 13 percent husk. The crown and its surface roots are not considered part of the stover.</p>
<p><strong><a title="Flax Straw" href="http://www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1226611043307&amp;lang=e">Flax Straw</a></strong><br />Flax straw is the fibrous stalk of a flax plant, left behind in the field after the flax seeds have been removed during combining. Unlike the straw of other crops commonly grown on the prairie, flax straw has a long history of being utilized, primarily for the strong fibers it contains. The ancient Egyptians produced fabrics from flax and wrapped their mummies in linen cloth.</p>
</p></div>
<p></span></p></blockquote>
<p>This is the kind of thing I write when I&#8217;m not primarily concerned with the lives and deaths of far-future genetically modified fish-people. Just thought you&#8217;d like to know. (Although, oddly enough, some people have referred to my stories about far-future genetically modified fish-people as a type of agricultural residue, so maybe there&#8217;s more unity to my career than I&#8217;d previously recognized.)</p>
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		<title>Genetic modification of large animals just got easier</title>
		<link>http://edwardwillett.com/2007/09/genetic-modification-of-large-animals-just-got-easier/</link>
		<comments>http://edwardwillett.com/2007/09/genetic-modification-of-large-animals-just-got-easier/#comments</comments>
		<pubDate>Fri, 21 Sep 2007 17:13:00 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
				<category><![CDATA[Blog]]></category>
		<category><![CDATA[biology]]></category>
		<category><![CDATA[biotechnology]]></category>
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		<guid isPermaLink="false">http://willett.pagedmedia.com/?p=2770</guid>
		<description><![CDATA[Efforts to genetically modify large animals have been hindered by the fact that the two methods currently used to effect it, somatic cell nuclear transfer or pronuclear injection, are costly, inefficient, difficult, and carry a risk of producing abnormal offspring. Now researchers at the University of Pennsylvania School of Veterinary Medicine have successfully produced genetically [...]]]></description>
			<content:encoded><![CDATA[<p><a href="http://lh5.google.com/ewillett/RvP7uda8mrI/AAAAAAAAAc0/BsYqtZDFzuM/Gene_therapy%5B3%5D.jpg"><img class="left" id="id" title="Gene Therapy" style="BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; BORDER-RIGHT-WIDTH: 0px" height="304" alt="Diagram illustrating the process of gene therapy" src="http://lh3.google.com/ewillett/RvP7u9a8msI/AAAAAAAAAc8/yccjfd5mQA4/Gene_therapy_thumb%5B1%5D.jpg" width="404" border="0" /></a></p>
<p>Efforts to genetically modify large animals have been hindered by the fact that the two methods currently used to effect it, <a title="Wikipedia article on somatic cell nuclear transfer" href="http://en.wikipedia.org/wiki/Somatic_cell_nuclear_transfer">somatic cell nuclear transfer</a> or <a title="Explanation of pronuclear injection from Tulane University" href="http://www.tulane.edu/~tgmouse/PRONUCLEAR.htm">pronuclear injection</a>, are costly, inefficient, difficult, and carry a risk of producing abnormal offspring. Now researchers at the <a title="University of Pennsylvania School of Veterinary Medicine" href="http://www.vet.upenn.edu/">University of Pennsylvania School of Veterinary Medicine</a> have <a title="Press release from University of Pennsylvania School of Veterinary Medicine" href="http://www.vet.upenn.edu/newsandevents/news/adeno.htm">successfully produced genetically modified mice and goats</a> by transferring modified genetic information via a harmless virus to male reproductive cells, which then passed the modification on naturally to about 10 percent of the offspring. In other words, genetic modification via <a title="Wikipedia article on gene therapy" href="http://en.wikipedia.org/wiki/Gene_therapy">gene therapy</a>.</p>
<p>Of course, using this technique on humans in combination with in-vitro fertilization and careful weeding of the resulting embryos in order to create a genetically modified super race with abilities surpassing normal humans&#8217; would be completely illegal and unethical, and only a deranged science fiction writer such as myself whose next book features genetically modified humans would even think of it as a possibility.</p>
<p>So, no worries.</p>
<p>(Via <em><a title="Original item on PhysOrg" href="http://www.physorg.com/news109518400.html">PhysOrg</a></em>.)</p>
<p>(Also posted to <em><a href="http://www.futurismic.com/">Futurismic</a></em>.)</p>
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		<title>Who needs a flash drive&#8230;</title>
		<link>http://edwardwillett.com/2007/02/who-needs-a-flash-drive/</link>
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		<pubDate>Fri, 16 Feb 2007 14:49:00 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
				<category><![CDATA[Blog]]></category>
		<category><![CDATA[biology]]></category>
		<category><![CDATA[biotechnology]]></category>
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		<category><![CDATA[DNA]]></category>
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		<guid isPermaLink="false">http://willett.pagedmedia.com/?p=2393</guid>
		<description><![CDATA[&#8230;when you&#8217;ve got DNA? Japanese scientists say it might be possible to use DNA to store text, images, music and other digital data for thousands of years inside living organisms. Masaru Tomita and colleagues at Tokyo&#8217;s Keio University say data encoded in an organism&#8217;s DNA, and inherited by each new generation, could be safely archived [...]]]></description>
			<content:encoded><![CDATA[<p>&#8230;<a href="http://www.physorg.com/news90780873.html">when you&#8217;ve got DNA</a>?</p>
<p><em>Japanese scientists say it might be possible to use DNA to store text, images, music and other digital data for thousands of years inside living organisms.</em></p>
<p><em>Masaru Tomita and colleagues at Tokyo&#8217;s Keio University say data encoded in an organism&#8217;s DNA, and inherited by each new generation, could be safely archived for hundreds of thousands of years, becoming the perfect storage medium. In contrast, CD-ROMs, flash memory and hard disk drives can easily fall victim to accidents or natural disasters.</em><br /><em></em><br /><em>The researchers describe a method for copying and pasting data, encoded as artificial DNA, into the genome of</em> Bacillus subtilis<em>, a common soil bacterium, &#8220;thus acquiring versatile data storage and the robustness of data inheritance.&#8221;</em><br /><em></em><br /><em>The scientists demonstrated the method by using a strain of B. subtilis to store the message: &#8220;E=MC2 1905!&#8221; &#8212; Albert Einstein&#8217;s famous 1905 energy-mass equivalence equation.</em><br /><em></em><br /><em>&#8220;We suggest that this simple, flexible and robust method offers a practical solution to data storage and retrieval challenges in combination with other, previously published techniques,&#8221; the report states.</em><br /><em></em><br /><em>The research is scheduled to appear in the April 9 issue of the journal</em> Biotechnology Progress<em>.</em></p>
<p>Science fictional twist: turns out Earth is nothing but a giant disk drive for ancient, superpowerful aliens, who have been storing records for millions of years in the DNA of life on this planet&#8230;and now they&#8217;ve decided it&#8217;s time to re-format&#8230;</p>
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		<title>Cotton: it&#8217;s what&#8217;s for dinner</title>
		<link>http://edwardwillett.com/2006/11/cotton-its-whats-for-dinner/</link>
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		<pubDate>Mon, 20 Nov 2006 16:48:00 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
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		<category><![CDATA[biotechnology]]></category>
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		<description><![CDATA[Or, at least, it could be soon: &#8220;The exciting finding is that we have been able to reduce gossypol – which is a very toxic compound – from cottonseed to a level that is considered safe for consumption,&#8221; said Dr. Keerti Rathore, Texas Agricultural Experiment Station plant biotechnologist. &#8220;In terms of human nutrition, it has [...]]]></description>
			<content:encoded><![CDATA[<p>Or, at least, it <a href="http://www.eurekalert.org/pub_releases/2006-11/tau--gct111506.php">could be soon</a>:</p>
<p><em>&#8220;The exciting finding is that we have been able to reduce gossypol – which is a very toxic compound – from cottonseed to a level that is considered safe for consumption,&#8221; said Dr. Keerti Rathore, Texas Agricultural Experiment Station plant biotechnologist. &#8220;In terms of human nutrition, it has a lot of potential.&#8221; The cottonseed from these plants meet World Health Organization and U.S. Food and Drug Administration standards for food consumption, he said, potentially making the seed a new, high-protein food available to 500 million people a year. </em></p>
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		<title>Genetic engineering</title>
		<link>http://edwardwillett.com/1991/03/genetic-engineering/</link>
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		<pubDate>Wed, 20 Mar 1991 11:51:31 +0000</pubDate>
		<dc:creator>Edward Willett</dc:creator>
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		<category><![CDATA[biotechnology]]></category>
		<category><![CDATA[genetic engineering]]></category>
		<category><![CDATA[genetically modified organisms]]></category>
		<category><![CDATA[genetics]]></category>
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		<description><![CDATA[Though the word &#8220;biotechnology&#8221; sounds very modern, what it describes has been with us for centuries&#8211;if you define it, as one science encyclopedia does, as &#8220;using biological organisms, systems or processes to make or modify products.&#8221; In other words, the first time somebody discovered the wondrous change wrought in grape juice by fermentation, or an [...]]]></description>
			<content:encoded><![CDATA[<p><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Though the word &#8220;biotechnology&#8221; sounds very modern, what it describes has been with us for centuries&#8211;if you define it, as one science encyclopedia does, as &#8220;using biological organisms, systems or processes to make or modify products.&#8221;</span></p>
<p><span style="font-family: Arial; font-size: small;">In other words, the first time somebody discovered the wondrous change wrought in grape juice by fermentation, or an excited baker got a little yeast in her dough and saw it swell up (think how brave whoever ate it must have been!), biotechnology was at work.</span></p>
<p><span style="font-family: Arial; font-size: small;">In a broader sense, all agriculture is biotechnology, using biological organisms (plants and animals) to make a product (food). Through the centuries, selective breeding has honed agricultural crops to the point where today&#8217;s plants bear little resemblance to their distant wild forefathers (foreflowers?) and probably could not survive in the wild. (Unlike weeds, whose overwhelming vigor is precisely what makes them a problem.)</span></p>
<p><span style="font-family: Arial; font-size: small;">Similarly, agricultural animals have been selectively bred over the millenia (there are references to attempts to breed specific traits in sheep in the Old Testament) until today&#8217;s beasts are really artificial creatures that, like modern crops, likely could not survive in the wild.</span></p>
<p><span style="font-family: Arial; font-size: small;">All of which just makes the point that attempting to improve useful species is something that mankind has been doing, albeit through the extremely slow process of selective breeding, throughout history and even pre-history. There may have been more luck to it than science&#8211;but it worked.</span></p>
<p><span style="font-family: Arial; font-size: small;">Today, we have a whole new tool with which to modify species. It&#8217;s called &#8220;genetic engineering.&#8221;</span></p>
<p><span style="font-family: Arial; font-size: small;">Genetic information&#8211;the information passed from an organism to its offspring&#8211;is contained in the incredibly small coils of DNA, a complex substance that can replicate itself. Engineering something too small to be seen might seem impossible at first. After all, you can&#8217;t go down to the hardware store and pick up a set of DNA screwdrivers and a molecular monkey wrench.</span></p>
<p><span style="font-family: Arial; font-size: small;">However, there are ways. Certain chemicals will cut particular pieces of DNA in exactly the same place every time, and others will join cut pieces back together again. Using these chemicals, called enzymes, scientists can take a piece of DNA containing just the genetic information they want (say, a gene from a bacterium that produces a chemical toxic to insects) into another organism (say, a rye plant) creating a crop which makes its own insecticide. (Saskatchewan scientists are doing precisely that.)</span></p>
<p><span style="font-family: Arial; font-size: small;">Genetic engineering is also used to increase resistance to disease; to produce microorganisms that in turn produce valuable medical substances such as insulin and interferon; to create bacteria that can clean up spills of oil and other toxic substances, and more. There&#8217;s little doubt the impact of this new form of biotechnology will outweigh the centuries of slow modification of species that preceded it, and it&#8217;s only beginning to be felt.</span></p>
<p><span style="font-family: Arial; font-size: small;">That being the case, what does the future hold?</span></p>
<p><span style="font-family: Arial; font-size: small;">Well, that depends on who you ask, how visionary they&#8217;re feeling that day, and whether they really like the idea of people rummaging around in the genetic attic.</span></p>
<p><span style="font-family: Arial; font-size: small;"> But here are a few predictions from various sources:</span></p>
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<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">By 2000, it&#8217;s estimated genetic engineering will add $20 billion annually to the value of world crops.<br />
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<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Cows could be genetically engineered to produce useful substances such as interferon in their milk. These substances could easily be extracted and purified, and the milk sold as usual.<br />
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<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Slaughter animals and their attendant problems could be done away with entirely; instead cloned, brainless slabs of beef, lamb, pork, chicken or any other meat could be grown in vats.<br />
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<td width="42" valign="baseline"><span style="font-family: Verdana, Arial, Helvetica;"><img src="http://edwardwillett.com/Columns/BD10268_.GIF" alt="" hspace="15" width="12" height="12" /></span></td>
<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Silk, cotton or flax could be produced by microorganisms growing in a fermentor.<br />
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<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Genetically engineered canola could produce chocolate&#8211;or, at least, something with the flavour and texture of chocolate.<br />
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<td width="42" valign="baseline"><span style="font-family: Verdana, Arial, Helvetica;"><img src="http://edwardwillett.com/Columns/BD10268_.GIF" alt="" hspace="15" width="12" height="12" /></span></td>
<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">The genetic damage that gives rise to diseases such as sickle cell anemia could be repaired, so that people suffering from such illnesses would be able to have children without worrying about passing on their disease to their offspring.<br />
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<td width="42" valign="baseline"><span style="font-family: Verdana, Arial, Helvetica;"><img src="http://edwardwillett.com/Columns/BD10268_.GIF" alt="" hspace="15" width="12" height="12" /></span></td>
<td width="100%" valign="top"><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">In the far, far future, human beings themselves could be &#8220;genegineered&#8221; into new forms. Imagine a race of humans with gills and webbed hands and feet, living beneath the ocean.</span></span></td>
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<p><span style="font-family: Verdana, Arial, Helvetica;"><span style="font-family: Arial; font-size: small;">Don&#8217;t hold your breath waiting for gills, but some of these other developments, and more we haven&#8217;t even thought of yet, may be just around the corner.</span></p>
<p><span style="font-family: Arial; font-size: small;">Are you ready for the age of designer genes?</span></p>
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