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The Holy Grail of hemophilia treatment
[podcast]http://edwardwillett.com/wp-content/uploads//2011/12/Hemophilia-Gene-Therapy.mp3[/podcast] Over more than two decades of science writing, I’ve seen a lot of my past writings rendered obsolete by scientific progress. Case in point: the release last week of a research report on exciting new progress in gene therapy for hemophiliacs. Back in 2001, I wrote a book on hemophilia for the Enslow Publishers series Diseases and People (<brag>School Library Journal called it: “An excellent resource for basic research for personal or academic use.”</brag>). Gene therapy—the insertion of genes into living cells in the human body to treat disorders—has always seemed to hold particular promise for the treatment of hemophilia because it is a genetic disease: you can’t catch it, you can only ...Cloning a mammoth
[podcast]http://edwardwillett.com/wp-content/upLoads//2011/01/Cloning-the-Mammoth.mp3[/podcast] One of the more striking exhibits at the Royal Saskatchewan Museum is the woolly mammoth that looms over you, emerging from a forest, when you round one of the corners in the Earth Sciences Gallery. Twelve thousand years ago, you might have encountered exactly that scene while strolling through Saskatchewan: these days, the closest you can come is a museum exhibit, because woolly mammoths are, of course, quite extinct. But gone forever? Perhaps not. As the hag tells Prince Caspian in the C.S. Lewis book of the same name, “You can always get them back.” Oh, sure, she was talking about the White Witch, but she could have been talking about ...A treatment for Ebola?
[podcast]http://edwardwillett.com/wp-content/upLoads//2010/06/A-Treatment-for-Ebola.mp3[/podcast] A few years ago I wrote several books for Enslow Publishers in New Jersey for a series called Diseases and People. I covered meningitis, arthritis, hemophilia...and Ebola. My most recent book for Enslow, Disease-Hunting Scientist, also talks about Ebola, and some of the scientists who travel to the sites of outbreaks to help with containment efforts. Ask someone on the street to name a particularly deadly disease, and there’s a good chance he’ll say “Ebola.” Yet of the diseases I wrote about, the biggest killer by far is meningitis, the bacterial form of which kills some 170,000 people every year, according to the World Health Organization. (And if you want even bigger killers, in sub-Saharan Africa alone tuberculosis kills some 5,000 ...A half-billion years of irritation
Just a couple of years ago, I wrote a column about the advent of tearless onions that included some background on why onions make us cry in the first place. Ordinarily I wouldn’t revisit a topic quite so soon, but you know how it is with science: things change fast, and just this week there was breaking news in the field of onion-induced tears. Well, as breaking as any news can be when it deals with something that’s been around for half a billion years. Onions have always made humans cry, or at least for as long as humans have been eating them, which seems to be a long time indeed—so far back in pre-history that we can’t even say for sure ...Tearless onions
Download the audio version.Get my science column weekly as a podcast.I’m a sensitive kinda guy. I fact, I’m so sensitive I sometimes tear up just during the process of making dinner.It’s not that I’m overcome with emotion at the blessing of having at my disposal the wherewithal to stir-fry. (I’m not that sensitive.) No, it’s usually because I’m slicing onions.Onions have been a part of the human diet since prehistoric times. We don’t even know where they originated: some say central Asia, others Iran or West Pakistan. (So I learned from the interesting history of onions I found on the website of the U.S.’s National Onion Association, an organization whose very ...One step closer to the return of the woolly mammoth?
Maybe. That's the focus of today's post at Futurismic; and thanks to Janet at The Walrus Said for the tip!Genetic modification of large animals just got easier
Efforts to genetically modify large animals have been hindered by the fact that the two methods currently used to effect it, somatic cell nuclear transfer or pronuclear injection, are costly, inefficient, difficult, and carry a risk of producing abnormal offspring. Now researchers at the University of Pennsylvania School of Veterinary Medicine have successfully produced genetically modified mice and goats by ...Neophobia
Download the audio version.Get my column as a podcast.***When I was a kid, I was a picky eater. I knew what I liked, I knew what I didn't like, and I knew what I was sure I wouldn't like if I ever tried it, which I had no intention of doing, because why should I force myself to eat something I already knew I didn't like?I remember my first visit to a Chinese restaurant. As the adults in our party chowed down on interesting concoctions of vegetables and noodles and meat in exotic sauces, I had a hamburger. They weren't getting me to eat that stuff!Of course, what goes ...A most appropriate presentation
This is cool:Nobel laureate James Watson – co-discoverer of the DNA double helix and father of the Human Genome Project – today, in a presentation at Baylor College of Medicine, became the first human to receive the data that encompass his personal genome sequence.It's astonishing how far we've come in genetics in such a short time.(Via Medgadget.)ADDENDUM: FuturePundit has more on why this is significant.Mini-DNA replicator
This is pretty amazing:A pocket-sized device that runs on two AA batteries and copies DNA as accurately as expensive lab equipment has been developed by researchers in the US. The device has no moving parts and costs just $10 to make. It runs polymerase chain reactions (PCRs), to generate billions of identical copies of a DNA strand, in as little as 20 minutes. This is much faster than the machines currently in use, which take several hours.Copying DNA is important for a number of medical tests, such as diagnosing tuberculosis. The hope is that devices like this may make high-tech medicine more readily available in developing countries.Maybe it'll bring down medical ...
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Magebane
“Spectacular” – Publishers Weekly (starred review)
“Evil wizards, multi-level conspiracies, hidden kingdoms…Lee Arthur Chane…has done a marvelous job…Magebane is a very entertaining book and well worth the time.” – A.M. Donovan, Night Owl Reviews
I happily recommend Magebane and I’ll certainly give Chane’s next novel a try based on this one.” —Bill Capossere, Fantasy Literature
“…an original and delightful tale of epic fantasy and magic, steampunk science, adventure, tragedy, and love…” – Errant Dreams Reviews
Eight centuries ago, the world changed. A devastating war swept the lands, and the MageLords, who had long ruled by virtue of their spell powers, were driven to a distant place, separated from those they had ruled by a magical Barrier. With magic banished from the rest of the world, the MageLords became mere legend and people turned to science to improve their lives. But if one man has his way, all that is about to change….
Written as Lee Arthur Chane (the middle names of my older brothers, Jimmy Lee and Dwight Arthur, and myself, Edward Chane Willett).
Marseguro
Winner of the 2009 Prix Aurora Award for Best Long-Form Work in English
Water world Marseguro is home to the Selkies, a water-dwelling race created from human DNA. When an unmodified human seeks revenge on a Selkie by activating a distress beacon taken from the remains of the original colony ship, a strikeforce is sent from Earth to eradicate the genetic abomination. Yet Marseguro will not prove as easy to conquer as the Earth force anticipates…
Terra Insegura
Finalist for the 2010 Prix Aurora Award for Best Novel in English
Marseguro, a water world far from Earth, is home to a colony of humans and the Selkies, a water-dwelling race created from modified human DNA. For seventy years the colony has lived in peace. Then Earth discovers Marseguro, and a strike force is sent to eradicate this “abomination.” But Marseguro has created a genetically tailored plague to use against Earth’s Holy Warriors. With the enemy defeated, the people of Marseguro feel they are safe. But Chris Keating, the traitor who signaled Marseguro’s location to the Holy Warriors, has fled to Earth, unknowingly carrying the deadly plague within him. The people of Marseguro feel they must send a ship to Earth with a life-saving vaccine. Only time will tell what awaits them when they reach their destination.
Lost in Translation
Kathryn was a human empath whose world and life had been destroyed when the alien S’sinn slaughtered her parents before her very eyes. Jarrikk was a young S’sinn, an unproven warrior who’d seen his flight mates slaughtered by the humans who’d sought to colonize his world.
As humans and S’sinn found themselves on the brink of war, these two Translators had to work together to find a common ground and avert catastrophe. But whether their Translators’ oath and training could overcome the enemies leagued against them was very much in doubt…
Archives
Song of the Sword
My new YA fantasy novel from Lobster Press
Before the Lady called her, Ariane’s life was a mess. Two years ago, her mother disappeared. She bounced around different foster homes until her aunt finally took her in. The meanest clique at her new high school has decided to make Ariane their prime target. And to top it all off, she is having frightening premonitions, and they are becoming more intense. The moment water touches her skin, she sees visions of a lake, a lady, and a sword. When a staircase opens up in the middle of Wascana Lake and the water begins singing to her, she has no choice but to answer the call….
Historic Walks of Regina and Moose Jaw
Ten walks to points of historic and architectural interest in the cities of Regina and Moose Jaw (eight walks for Regina, two for Moose Jaw).
Johnny Cash: The Man in Black
When country music legend Johnny Cash took the stage at Folsom State Prison in 1968, he solidified the public’s perception of him as a rebel who followed his own path. Born in Arkansas during the Great Depression, Cash endured poverty, the death of his older brother, and a difficult relationship with his father. He turned to gospel and country music to express the pain, and after many years of struggling, his songs of hardship and hope would finally reach the ears of those waiting for an artist who represented them, ordinary people fighting to survive.
Andy Warhol: Everyone Will Be Famous for 15 Minutes
“Paintings are too hard. Machines have less problems…” In the 1960s, Andy Warhol became the most famous creator of a new style of art called pop art, which transformed mass-produced items of popular culture into fine works of art. From Campbell’s Soup cans to photographs of Marilyn Monroe, Warhol’s willingness to use anything and everything from the mass media in his work expanded the range of subject matter available to artists. His avant-garde films, artistic usage of American icons, and unconventional social life made him a controversial figure, both greatly admired and deeply reviled. A trendsetter rather than a trend-follower, a dispassionate observer of both the seamy and celebrity sides of life, Warhol was a true American rebel.
Disease-Hunting Scientist
The true stories of six real disease hunters. Epidemiologists travel the world trying to keep us safe from deadly diseases—from high-tech labs in Canada to remote villages in Africa. Learn how these “disease detectives” are coming up with new ways to fight disease, and find out if you have what it takes to become an epidemiologist, too!
The Bounty Mutiny
The Bounty was a British ship visiting Tahiti in 1789 when some of the crew overthrew the captain, William Bligh, and set him adrift in a tiny boat with sailors loyal to him. The mutiny resulted in a number of trials–both of the men who mutinied and of Bligh for losing command of his ship. These fascinating events have been the source for numerous Hollywood movies, most recently The Bounty. The Bounty Mutiny: From the Court Case to the Movie explores the famous case and the movies it inspired.
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